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商品详情：

英文名称：H9N2 Hemagglutinin HA1

中文名称：A型流感病毒（H9N2）血凝素HA1抗体

别    名；ha; HA1; HA2; Hemagglutinin; HEMA_I66A1; Hemagglutinin HA1 chain; Hemagglutinin HA2 chain; Hemagglutinin precursor; Influenza A virus (strain A/Turkey/Wisconsin/1/1966 H9N2).

研究领域；细菌及病毒

抗体来源；Rabbit

克隆类型；Polyclonal

产品应用；ELISA=1:5000-10000

not yet tested in other applications.

optimal dilutions/concentrations should be determined by the end user.

理论分子量；61kDa

细胞定位；细胞膜

性    状；Liquid

浓    度；1mg/ml

免 疫 原；KLH conjugated synthetic peptide derived from Influenza A Hemagglutin HA1 Influenza A Hemagglutin HA1: 361-360/560 <Extracellular>

亚    型；IgG

纯化方法；affinity purified by Protein A

缓 冲 液；0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存条件；Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.

注意事项；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

产品介绍；Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. Novel influenza virus strains caused by genetic drift and viral recombination emerge periodically to which humans have little or no immunity, resulting in devastating pandemics. Influenza A can exist in a variety of animals; however it is in birds that all subtypes can be found. These subtypes are classified based on the combination of the virus coat glycoproteins hemagglutinin (HA) and neuraminidase (NA) subtypes. HA interacts with cell surface proteins containing oligosaccharides with terminal sialyl residues. Virus isolated from a human infected with the H5N1 strain in 1997 could bind to oligosaccharides from human as well as avian sources, indicating its species-jumping ability.

Function:

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent athway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.